LDN – Coronavirus (English)

Can LDN Help Prevent Coronavirus COVID-19? This is a question LDNscience is increasingly being asked. Let’s divide this question into parts:

What are the dangers of coronavirus?

Coronavirus (COVID-19) poses little danger to the vast majority of people. However, people above the age of 60, as well as those with pre-existing medical conditions, are at increased risk of complications from coronavirus infection. The virus can cause a significant inflammatory reaction that can damage the lining of the lungs and induce systemic over-clotting, leading to multi-organ failure. This is why part of the treatment for seriously-affected coronavirus patients includes immune-suppressants like steroids/cortisone, in order to suppress the massive immune-stimulated inflammatory reaction. However, this is a double-edged sword, as the same immunosuppressants can also lead to the virus multiplying out of control. To try to counter-balance this problem, the treatment for COVID-19 combines antiviral drugs too.

Does LDN have antiviral activity?

Yes! LDN’s antiviral activity is indirect but clear. LDN stimulates the body’s production of OGF — an endorphin (or feel-good hormone) produced naturally by the body, but which is deficient in patients with autoimmune diseases, cancers, and compromised immune systems. Importantly, OGF is a key stimulator of the production of, and normalization of the levels of, the body’s natural antiviral warriors, called “interferon” molecules.

LDN’s antiviral and immune-normalizing activity was shown 35 years ago in a 1985 study by Dr. Bernard Bihari in HIV/AIDS patients in New York. These results have been corroborated in two studies conducted in Mali that were published in 2011. LDN is also widely used by patients with viral-induced conditions such as Epstein-Barr Virus and Cytomegalovirus, some of whom report significant benefits. 

Why are there warnings to avoid anti-inflammatory drugs, and why is LDN different?

Warnings to avoid taking anti-inflammatories such as ibuprofen have been circulating on the internet, with the claim that taking them is associated with a greater chance of acquiring the infection. Interestingly, some researchers approached about this issue have stated that there is no scientific basis for this claim. For instance, the Irish Health Authorities have declared it to be completely inaccurate. However, while it’s likely that there is no impact of taking ibuprofen on getting the coronavirus, ibuprofen and similar drugs do carry other risks such as compromising kidney function, which may be a problem in those seriously affected by COVID-19. 

As we can see, while too little immunity increases the risk of acquiring the COVID-19 infection and its complications, too much immunity (i.e. inflammation) can destroy the lungs and essential organs. LDN is not a classic anti-inflammatory, but acts more like an immune-regulator that works to normalize inflammation levels – without suppressing the immune system. LDN may balance immune system function providing additional protection from infection and harm, yet reducing the risk of the destructive hyper-inflammation reaction.

Will the LDN supply be affected by the Chinese factory shutdown?

Most of the world’s production of naltrexone actually comes from the US, Italy, and India. While production of naltrexone in Italy and China may indeed be impacted, the manufacturer has plenty of stores of the drug in its Swiss warehouses. We don’t expect that there will be a shortage of LDN in the coming months, despite the increased demand. 


To your good health, 
The LDNscience® Team

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MedInsight® Research Institute